ParkinsonCanadaV1, Main, Exploration, bibRecord, 002035

Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [15O] H2O PET study

Identifieur interne : 002035 ( Main/Exploration ); précédent : 002034; suivant : 002036

Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [15O] H2O PET study

Auteurs : Benedicte Ballanger [Canada] ; Andres M. Lozano [Canada] ; Elena Moro [Canada] ; Thilo Van Eimeren [Canada] ; Clement Hamani [Canada] ; Robert Chen [Canada] ; Roberto Cilia [Canada] ; Sylvain Houle [Canada] ; Yu Yan Poon [Canada] ; Anthony E. Lang [Canada] ; Antonio P. Strafella [Canada]

Source :

Human Brain Mapping [ 1065-9471 ] ; 2009-12.

RBID : ISTEX:48DDDE5AB48033FA79EF7A5E0DA06978F23B9411

Descripteurs français

Pascal (Inist)
- Débit sanguin, Encéphale, Homme, Locomotion, Maladie de Parkinson, Mésencéphale, Noyau pédonculopontin, Parkinsonisme, Pathologie du système nerveux, Radiodiagnostic, Stade avancé, Stimulation cérébrale profonde, Tomographie par émission de positons, Tomoscintigraphie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Advanced stage, Aged, Blood flow, Brain Mapping, Cerebrovascular Circulation (physiology), Deep Brain Stimulation (methods), Deep brain stimulation, Electrodes, Implanted, Emission tomography, Encephalon, Human, Humans, Image Interpretation, Computer-Assisted, Locomotion, Male, Midbrain, Motor Skills (physiology), Nervous system diseases, Oxygen Radioisotopes, Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinsonism, Pedunculopontine Tegmental Nucleus (blood supply), Pedunculopontine Tegmental Nucleus (diagnostic imaging), Pedunculopontine Tegmental Nucleus (physiopathology), Pedunculopontine nucleus, Positron emission tomography, Positron-Emission Tomography, Radiodiagnosis, Radiopharmaceuticals, deep brain stimulation, imaging, locomotion, midbrain.
MESH :
- chemical : Oxygen Radioisotopes, Radiopharmaceuticals.
- blood supply : Pedunculopontine Tegmental Nucleus.
- diagnostic imaging : Parkinson Disease, Pedunculopontine Tegmental Nucleus.
- methods : Deep Brain Stimulation.
- physiology : Cerebrovascular Circulation, Motor Skills.
- physiopathology : Parkinson Disease, Pedunculopontine Tegmental Nucleus.
- therapy : Parkinson Disease.
- Aged, Brain Mapping, Electrodes, Implanted, Humans, Image Interpretation, Computer-Assisted, Male, Positron-Emission Tomography.

Abstract

Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement sleep]. Recent reports suggested that PPN modulation with deep brain stimulation (DBS) may be beneficial in the treatment of axial symptoms. However, the mechanisms underlying these effects are still unknown. We used [15O] H2O PET to investigate regional cerebral blood flow in three patients with advanced PD who underwent a new experimental surgical procedure with implantation of unilateral PPN‐DBS. Patients were studied Off‐medication with stimulator Off and On, both at rest and during a self‐paced alternating motor task of the lower limbs. We used SPM2 for imaging data analysis, threshold P < 0.05 corrected at the cluster level. Stimulation induced significant regional cerebral blood flow increment in subcortical regions such as the thalamus (P < 0.006), cerebellum (P < 0.001), and midbrain region (P < 0.001) as well as different cortical areas involving medial sensorimotor cortex extending into caudal supplementary motor area (BA 4/6; P < 0.001). PPN‐DBS in advanced PD resulted in blood flow and presumably neuronal activity changes in subcortical and cortical areas involved in balance and motor control, including the mesencephalic locomotor region (e.g. PPN) and closely interconnected structures within the cerebello‐(rubro)‐thalamo‐cortical circuit. Whether these findings are associated with the DBS‐PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.

Url:

https://api-v5.istex.fr/document/48DDDE5AB48033FA79EF7A5E0DA06978F23B9411/fulltext/pdf

DOI: 10.1002/hbm.20815

Affiliations:

Le document en format XML

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<term>Aged</term>
<term>Blood flow</term>
<term>Brain Mapping</term>
<term>Cerebrovascular Circulation (physiology)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Deep brain stimulation</term>
<term>Electrodes, Implanted</term>
<term>Emission tomography</term>
<term>Encephalon</term>
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<term>Humans</term>
<term>Image Interpretation, Computer-Assisted</term>
<term>Locomotion</term>
<term>Male</term>
<term>Midbrain</term>
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<term>Nervous system diseases</term>
<term>Oxygen Radioisotopes</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
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<term>Pedunculopontine Tegmental Nucleus (blood supply)</term>
<term>Pedunculopontine Tegmental Nucleus (diagnostic imaging)</term>
<term>Pedunculopontine Tegmental Nucleus (physiopathology)</term>
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<term>Positron emission tomography</term>
<term>Positron-Emission Tomography</term>
<term>Radiodiagnosis</term>
<term>Radiopharmaceuticals</term>
<term>deep brain stimulation</term>
<term>imaging</term>
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<term>Brain Mapping</term>
<term>Electrodes, Implanted</term>
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<term>Encéphale</term>
<term>Homme</term>
<term>Locomotion</term>
<term>Maladie de Parkinson</term>
<term>Mésencéphale</term>
<term>Noyau pédonculopontin</term>
<term>Parkinsonisme</term>
<term>Pathologie du   système nerveux</term>
<term>Radiodiagnostic</term>
<term>Stade avancé</term>
<term>Stimulation cérébrale profonde</term>
<term>Tomographie par émission de positons</term>
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<front><div type="abstract" xml:lang="en">Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy. The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement sleep]. Recent reports suggested that PPN modulation with deep brain stimulation (DBS) may be beneficial in the treatment of axial symptoms. However, the mechanisms underlying these effects are still unknown. We used [15O] H2O PET to investigate regional cerebral blood flow in three patients with advanced PD who underwent a new experimental surgical procedure with implantation of unilateral PPN‐DBS. Patients were studied Off‐medication with stimulator Off and On, both at rest and during a self‐paced alternating motor task of the lower limbs. We used SPM2 for imaging data analysis, threshold P < 0.05 corrected at the cluster level. Stimulation induced significant regional cerebral blood flow increment in subcortical regions such as the thalamus (P < 0.006), cerebellum (P < 0.001), and midbrain region (P < 0.001) as well as different cortical areas involving medial sensorimotor cortex extending into caudal supplementary motor area (BA 4/6; P < 0.001). PPN‐DBS in advanced PD resulted in blood flow and presumably neuronal activity changes in subcortical and cortical areas involved in balance and motor control, including the mesencephalic locomotor region (e.g. PPN) and closely interconnected structures within the cerebello‐(rubro)‐thalamo‐cortical circuit. Whether these findings are associated with the DBS‐PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
</region>
<name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name>
<name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name>
<name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name>
<name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name>
<name sortKey="Cilia, Roberto" sort="Cilia, Roberto" uniqKey="Cilia R" first="Roberto" last="Cilia">Roberto Cilia</name>
<name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
<name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
<name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
<name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu Yan" last="Poon">Yu Yan Poon</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
<name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name>
<name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name>
<name sortKey="Van Eimeren, Thilo" sort="Van Eimeren, Thilo" uniqKey="Van Eimeren T" first="Thilo" last="Van Eimeren">Thilo Van Eimeren</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [15O] H2O PET study

Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [15O] H2O PET study

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